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B016182 - GENETICS AND EVOLUTION OG MICRORGANISMS
Main information
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2017-18
Coorte 2016 - Second Cycle Degree in BIOLOGY
Course year
Second year - Second Semester
Belonging Department
Biology (BIO)
Course Type
Single education field course
Scientific Area
BIO/18 - GENETICS
Credits
6
Teaching Hours
48
Teaching Term
26/02/2018 ⇒ 15/06/2018
Attendance required
No
Type of Evaluation
Final Grade
Course Content
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Course program
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Lectureship
Course Content
Origin of life. The RNA world. The DNA world. Molecular mechanisms for the construction of new genes. Origin and evolution of metabolic pathways Operons and regulonsMetabolons. The horizontal gene transfer. LUCA: the Last Universal Common Ancestor. Molecular phylogeny. The three domains of life. The origin of eukaryotes. Symbiosis and endosymbiois. Pre-and post-adaptive mutations. Genomes evolution.
Suggested readings (Search our library's catalogue)
Peter J. Russell
Genetics. A molecular approach
Third Edition
Genetics. A molecular approach
Third Edition
Learning Objectives
Knowledge acquired (at the end of the course):
Advanced knowledge of microbial genetics. Knowledge of mechanisms responsible for the origin and evolution of genes, genomes, (micro)organisms and mechanisms responsible for the regulation of gene expression. Knowledge about the hypotheses on the origin of Life on Earth and the first stages of molecular and cellular evolution.
Competence acquired (at the end of the course):
Hypothesis on the origin and evolution of Life on Earth. Molecular and cellular evolution. Hypotheses on the origin and evolution of metabolic pathways. Mechanisms and forces driving the evolution of genes and genomes. Bacterial genetics. Hypotheses on the origin of Eukaryotes.
Skills acquired (at the end of the course):
Application of genetic methodologies for the sudty of origin and evolution of genes, genomes and metabolic pathways. The use of directed evolution experiments to study the genome plasticity.
Knowledge of evolutionary models at molecular and cellular level.
Advanced knowledge of microbial genetics. Knowledge of mechanisms responsible for the origin and evolution of genes, genomes, (micro)organisms and mechanisms responsible for the regulation of gene expression. Knowledge about the hypotheses on the origin of Life on Earth and the first stages of molecular and cellular evolution.
Competence acquired (at the end of the course):
Hypothesis on the origin and evolution of Life on Earth. Molecular and cellular evolution. Hypotheses on the origin and evolution of metabolic pathways. Mechanisms and forces driving the evolution of genes and genomes. Bacterial genetics. Hypotheses on the origin of Eukaryotes.
Skills acquired (at the end of the course):
Application of genetic methodologies for the sudty of origin and evolution of genes, genomes and metabolic pathways. The use of directed evolution experiments to study the genome plasticity.
Knowledge of evolutionary models at molecular and cellular level.
Prerequisites
Courses to be used as requirements (required and/or recommended)
Courses required: Genetics
Courses recommmended: Biochemistry, Microbiology, Generale and Inorganic Chemistry, Organic chemistry
Courses required: Genetics
Courses recommmended: Biochemistry, Microbiology, Generale and Inorganic Chemistry, Organic chemistry
Teaching Methods
Total hours of the course (including the time spent in attending lectures, seminars, private study, examinations, etc...): 150 (25x 6)
Hours reserved to private study and other individual formative activities:
Contact hours for: Lectures (hours): 48
Contact hours for: Laboratory (hours): 0
Contact hours for: Laboratory-field/practice (hours): 0
Seminars (hours): 0
Stages: 0
Intermediate examinations: 0
Hours reserved to private study and other individual formative activities:
Contact hours for: Lectures (hours): 48
Contact hours for: Laboratory (hours): 0
Contact hours for: Laboratory-field/practice (hours): 0
Seminars (hours): 0
Stages: 0
Intermediate examinations: 0
Further information
Frequency of lectures, practice and lab:
Lectures (two hours long) two times in the week. Highly recommended
Teaching tools
Additional teaching material will be provided during lectures.
Office hours:
Wednesday
By appointment
15,00-18,00
Tel 055-4574742
Email: renato.fani@unifi.it
Lectures (two hours long) two times in the week. Highly recommended
Teaching tools
Additional teaching material will be provided during lectures.
Office hours:
Wednesday
By appointment
15,00-18,00
Tel 055-4574742
Email: renato.fani@unifi.it
Type of Assessment
Exam modality:
Oral examination
Oral examination
Course program
Origin of life. The RNA world. The DNA world. Molecular mechanisms for the construction of new genes. Origin and evolution of metabolic pathways: nitrogen fixation and histidine biosynthesis. The role of gene duplication in genes and genomes evolution. Operons and regulons: origin and evolution. Metabolons. The horizontal gene transfer. LUCA: the Last Universal Common Ancestor: genetic and metabolic features. Molecular phylogeny. The three domains of life: Archaea, Bacteria and Eucarya. The origin of eukaryotes. Symbiosis and endosymbiois. Pre-and post-adaptive mutations. Genomes evolution: comprative genomics.
The directed evolution experiments. Heterologous gene expression
The directed evolution experiments. Heterologous gene expression