Course teached as: B016691 - TOSSICOLOGIA 5-years Single Cycle Degree in PHARMACY
Teaching Language
Italian
Course Content
Basic toxicology principles. Toxicological risk evaluation: acute and repeated toxicity, in vitro and epidemiological studies. Mechanisms of molecular and cellular damage. Theratogenesis, mutagenesis, carcinogenesis. Organ systems: hepatic, renal, cardiac, haematic, pulmonary, dermal, ocular toxicology, toxicology of the reproductive, immune, nervous system. Toxicology of heavy metals, solvents, pesticides, environmental pollutants, radiations and electromagnetic fields. Food toxicology.
• Casarett & Doull’s TOXICOLOGY: The Basic Science of Poisons, Editor: C.D. Klassen, VIII° ed. McGraw Hill Professional.
• Casarett & Doull’s ESSENTIALS OF TOXICOLOGY: I fondamenti dell’azione delle sostanze tossiche, Editor: L.J. Casarett, C.D. Klassen & J.B. Watkins, ed. McGraw-Hill Companies.
• PRINCIPLES AND METHODS OF TOXICOLOGY, Editor: A. W. Hayes, Va ed. Raven Press, New York.
Learning Objectives
The course provides the basic principles of toxicology, mechanisms of toxicity and toxicological risk evaluation, and an overview of the main classes of toxic substances, including toxic effects of drugs.
Prerequisites
Courses to be used as requirements (required):
Biochemistry, General Pharmacology, Pharmacology and Pharmacotherapy I
Teaching Methods
Frontal lessons supported by slides, available to students to the UNIFI e-learning platform.
Type of Assessment
Oral examination. Inscription to exams is done online.
Course program
Basic principles in Toxicology. Toxicological risk evaluation: acute and repeated toxicity studies, in vitro studies, epidemiological studies. Mechanisms of cellular and molecular damage and repair. Theratogenesis, mutagenesis, carcinogenesis. Toxicology of organ systems: hepatic, renal, cardiac, haematic, pulmonary, dermal, reproductive, immune, nervous system toxicology. Toxicology of heavy metals, solvents, pesticides, environmental pollutants, radiations and electromagnetic fields. Food toxicology.