Natural products of secondary metabolism. Biosynthetic building blocks and biogenetic pathways. The acetate pathway: polyketides. Mevalonic acid pathway: Terpenes and Steroids. The Shikimic acid pathways. Alkaloids. Beta-Lactam antibiotics.
P. M. Dewick
Chimica biosintesi e bioattività delle sostanze naturali
Edizione italiana
Piccin 2001
Learning Objectives
The acquisition by the student of the knowledge of the biosynthetic processes leading to the synthesis of natural products, and of the structure and properties of the most important classes of natural products
Prerequisites
Organic Chemistry I and II courses of a three year degree in Chemistry
Teaching Methods
Theoretical lessons with the projection of slides and the execution of exercises on the blackboard
Further information
Handouts and slides of the course are available on the Moodle platform
Type of Assessment
Learning will be verified through an oral examination in which the student will have to demonstrate knowledge of the biosynthetic processes leading to the synthesis of natural products and sufficient logical ability to correlate the different topics
Course program
Natural products of secondary metabolism. Biosynthetic building blocks and biogenetic pathways. The acetate pathway: polyketides (fatty acids, prostaglandins, aromatic polyketides, tetracyclines, macrolides and polyethers). Mevalonic acid pathway: Terpenes and Steroids (hemi-, mono-, sesqui-, di-, tri-, and tetraterpenes, Steroids, Cholesterol, Saponines, Phytosterols, group D vitamines, Cortisone, sex hormones). The Shikimic acid pathways (cynnamic acids, lignans and lignine, phenylpropanes and benzoic acids, cumarines, flavonoids). Alkaloids (from ornithine and lysine, pyrrolizidine, piperidine, quinolizidine, and indolizidine alk., from nicotinic acid, tyrosine, and tryptophan, purine). Beta-Lactam antibiotics (penicillins, cephalosporins).