Benzene and aromaticity. Hückel MO Theory. Aromatic electrophilic and nucleophilic substitution. Synthesis and reactivity of aromatic compounds. Pericyclic reactions. Bifunctional compounds. Carbocations and carbanions. Enolate anion. Direct aldol, Claisen and Dieckmann condensations. alfa,beta-Unsaturated carbonyl compounds. Michael reaction. Syntheses from acetoacetic and malonic esters. Lipids. Amino acids. Carbohydrates.
Laboratory: Mass and NMR Spectroscopy (1H and 13C)
Organic Chemistry text books for Chemistry Laurea degree. The same text can cover also the Organic Chemistry I and II courses.
Learning Objectives
The course is complementary to the course of Organic Chemistry I and aims to furnish the student with the complete picture of structure and reactivity of organic compounds, including several classes of natural products like lipids, amino acids, carbohydrates.
Prerequisites
Courses required: none
Courses recommended: none
Teaching Methods
Total number of hours for Lectures (hours): 40
Total number of hours for Laboratory-field practice : 15
Type of Assessment
Students have numerous dates available in June, July, September, November, and February to attend the oral examination.
The students at the end of the course have to attend a written test on theoretical aspects of Mass and NMR Spectrometry, and structural assignment via Mass and NMR Spectrometry.
The written test is prerequisite to the oral examination.
Course program
Benzene and aromaticity. Hückel MO Theory. Aromatic electrophilic and nucleophilic substitution. Synthesis and reactivity of aromatic compounds. Pericyclic reactions. Bifunctional compounds. Carbocations and carbanions. Enolate anion. Direct aldol, Claisen and Dieckmann condensations. alfa,beta-Unsaturated carbonyl compounds. Michael reaction. Syntheses from acetoacetic and malonic esters. Lipids. Amino acids. Carbohydrates. Brief analysis of heterocyclic compounds.
Laboratory: Mass and NMR Spectroscopy (1H and 13C)