Molecular events that underlie the cellular and/or systemic drug effects. Active drugs on receptor channels and G-protein coupled receptors. Intracellular receptors. Pharmacology of gene transcription. Pharmacological use of synthetic oligonucleotides and principles of gene therapy. Drugs and ion channels: Drugs and enzymes: Aspirin and FANS (non-steroidal anti-inflammatory agents). Drugs and carriers. Molecular basis on action mechanism of the major chemiotherapic and antineoplastic agents
Farmacologia Generale e Molecolare, a cura di Clementi F. e Fumagalli G, UTET.
Pharmacology, Rang HP, Dale MM, Ritter JM e Moore P, K, Casa editrice Ambrosiana
Learning Objectives
Advances on cellular and molecular mechanisms of drugs.
Drugs as powerful research tools important to highlight many biological phenomena.
Development of new and more modern drugs that plays a role in cellular and molecular mechanisms.
Prerequisites
none
Teaching Methods
6 CFU
Lectures (hours): 42
Contact hours for: Laboratory (hours): 6
Type of Assessment
Oral exam
Course program
Structure / nature of the cellular targets by which drugs interact and molecular events underlying the cellular and/or systemic effects of drugs. Drugs acting on the receptor-channels, G-protein-coupled receptors and receptors associated with tyrosine kinases. Cellular mechanisms of tolerance and dependence of drugs. Cytokine receptors and functions. Intracellular receptors. Use of synthetic oligonucleotides and pharmacological principles of gene therapy. Monoclonal antibodies. Intra-and extracellular proteolysis. Drugs and ion channels. Drugs and enzymes: aspirin and FANS (non-steroidal anti-inflammatory agents). Drugs and carriers. Mechanism of action of the major chemiotherapic and antineoplastic agents: molecular basis.